Product Code TMS 08
Anti-tuberculosis drugs have been used for many decades and resistance to them is now widespread. M. tuberculosis may be resistance to one or more drugs. Anti-tuberculosis drug resistance is a major public health problem which arises due to improper and irrational use of anti-tuberculosis drugs in chemotherapy of drug-susceptible tuberculosis patients. This improper use is a result of a number of actions including administration of improper treatment regimens, and failure to ensure that patients complete the whole course of treatment. A patient who develops active disease with a drug resistant tuberculosis strain can transmit this form of tuberculosis to other individuals.
Based on invitro correlation between the clinical response to antimicrobial agent and the result of invitro susceptibility testing kit helps in diagnosing the sensitivity pattern of M. tuberculosis affected patient and accordingly provide treatment, drug therapy for the patients.
Mycobacteria susceptibility test can be inoculated either directly from digested and concentrated smear positive sputum (direct test) or from a pure culture of Mycobacteria isolated from a clinical specimen (indirect test). The direct test is usually done only on specimens showing Mycobacteria on smear and give the best results when large no. of Mycobacteria are present. The advantage of the direct test is that a much earlier report of susceptibility studies (3 to 4 weeks) can be made than with indirect test which may take up to 5 to 7 weeks, but can be frequently be complicated by over growth with other bacteria that have survived
with seven antitubular drugs (Kanamycin, Amikacin, Ethionamide, D-Cycloserine, Clarithromycin Cipro?oxacin, p-Amino salicyclic acid) + 3 controls
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